Figure 1 (IMAGE)

Institute for Basic Science

Figure 1

Caption

Molecular mechanisms of severe reactive astrocytes-induced neurodegeneration in Alzheimer’s disease. When astrocytes are exposed to toxic materials, such as amyloid plaques, their properties change, morphologically and functionally, and transform into reactive states. When the reactive astrocytes are severely induced, all the pathological features of Alzheimer’s disease, including neurodegeneration, are precipitated. In this process, we found that the increase of MAO-B activity and the production of hydrogen peroxide play an important role in the progression of Alzheimer’s disease.

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