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The cells in vivo are very active so they emit lots of electricity and can be considered the cause of arrhythmia. The research group looked at the ratio of such cells at two weeks, four weeks and twelve weeks. Unfortunately there is no perfect marker for the nodal-like cells. They are observed through HCN4 and TBX3 but they are not perfect so it can't be declared as nodal-like, but all three, HCN4, SHOX2 and TBX3 decrease in abundance by twelve weeks.
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