Combined Recognition Strategy Allows CAR T Cells to Kill Solid Tumors in Mice and Avoid Side Effects (3 of 3) (VIDEO)
Caption
Movie shows how smart SynNotch-CAR T cells can precisely target glioblastoma brain tumors. The engineered T cells only activate when they reach the brain, and unleashing their killing activity selectively on the tumor. This material relates to a paper that appeared in the Apr. 28, 2021, issue of Science Translational Medicine, published by AAAS. The paper, by J.H. Choe at University of California, San Francisco in San Francisco, CA; and colleagues was titled, "SynNotch-CAR T cells overcome challenges of specificity, heterogeneity, and persistence in treating glioblastoma."
Credit
Wendell Lim and Payal Watchmaker
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