Mini-population analysis of nematode healthy lifespan by C-HAS (IMAGE)
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Top: A mini-population analysis of nematode healthy lifespan using a combination of C-HAS and statistical analysis of nematodes with the same genetic background. About 28% of the population had average lifespans, about 30% had long and healthy lifespans, about 35% were healthy but died prematurely, and about 7% had long periods of frailty.
Bottom: Activation of AMP-activated protein kinase (AMPK), an enzyme that has been linked to healthy lifespan, through genetics or with the drug metformin dramatically increased the healthy longevity of the C. elegans population.
Credit
Associate Professor Tsuyoshi Shuto
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<p>Adapted from (top) Fig 4(G, K), (bottom left) Fig 4(I, M), (bottom right) Fig 4(H, L) of <a href="https://www.sciencedirect.com/science/article/pii/S1347861320301237"> Nakano, Y. et.al. 2020</a>. </p> <p>This image is made available under the terms of <a href="https://creativecommons.org/licenses/by-nc-nd/4.0/"> CC BY-NC-ND 4.0</a>. Any further distribution of this work must follow the terms of this license. </p>
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