Mini-population analysis of nematode healthy lifespan by C-HAS (IMAGE)
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<p>Top: A mini-population analysis of nematode healthy lifespan using a combination of C-HAS and statistical analysis of nematodes with the same genetic background. About 28% of the population had average lifespans, about 30% had long and healthy lifespans, about 35% were healthy but died prematurely, and about 7% had long periods of frailty. </p> <p>Bottom: Activation of AMP-activated protein kinase (AMPK), an enzyme that has been linked to healthy lifespan, through genetics or with the drug metformin dramatically increased the healthy longevity of the <i>C. elegans</i> population. </p>
Credit
Associate Professor Tsuyoshi Shuto
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<p>Adapted from (top) Fig 4(G, K), (bottom left) Fig 4(I, M), (bottom right) Fig 4(H, L) of <a href="https://www.sciencedirect.com/science/article/pii/S1347861320301237"> Nakano, Y. et.al. 2020</a>. </p> <p>This image is made available under the terms of <a href="https://creativecommons.org/licenses/by-nc-nd/4.0/"> CC BY-NC-ND 4.0</a>. Any further distribution of this work must follow the terms of this license. </p>
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