Cryo-MOST Imaging System (IMAGE) Optica Caption The cryo-MOST imaging system allows whole-brain mapping of senile plaques in the mouse brain. The system cools the sample by keeping it immersed in liquid nitrogen to enhance fluorescence from senile plaques. For whole-brain imaging, the XYZ stages move the sample to automatically alternate between imaging and the miller machine that removes a layer of the tissue each time the surface is imaged. Credit Jing Yuan, Huazhong University of Science and Technology Usage Restrictions None License Licensed content Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.