4 Versions of a Gene's Message (IMAGE)

Cold Spring Harbor Laboratory

4 Versions of a Gene's Message

Caption

A gene can give rise to multiple RNA messages, each resulting in a different variant, or isoform. Here are the 4 messenger RNA isoforms generated by the human AFMID gene. From top: two isoforms normally found in adult cells. Lower two variants are missing some of the 11 segements, called exons, in the main isoform; these give rise to truncated proteins associated with liver cancer.

Credit

Krainer Lab, CSHL

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