EED Silencing Target Gene Activity (VIDEO)
Caption
By combining synthetic biology approaches with time-lapse movies that track the behaviors of individual cells, a team led by Caltech biologists has determined how four members of a class of proteins known as chromatin regulators establish and control a cell's ability to maintain a particular state of gene expression. In this movie, recruitment of EED (one of the four regulators tested by the group) completely silences, or turns off, the target gene, which codes for a fluorescent protein. Cells with active genes appear green. Here, it typically takes each cell longer to silence the gene, and therefore turn black (compared to KRAB silencing). In addition, the delay before silencing occurs varies widely between individual cells.
Credit
L. Bintu, J. Yong, and M.B. Elowitz / Caltech
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