Most Individuals Harbor B Cells Sensitive to HIV-fighting Immunogen (2 of 2) (IMAGE)

American Association for the Advancement of Science (AAAS)

Most Individuals Harbor B Cells Sensitive to HIV-fighting Immunogen (2 of 2)

Caption

An immunogen named eOD-GT8 was designed to bind and activate the predicted human germline precursor B cells of the VRC01 class of HIV broadly neutralizing antibodies (bnAbs). As a test, eOD-GT8 was used as a probe to isolate human naive B cells from HIV-uninfected individuals. This process pulled out VRC01-class human precursor B cells, confirming the design and suggesting that eOD-GT8 immunogens should be further tested in a human vaccine setting to determine if eOD-GT8 can activate the targeted VRC01-class B cells as a first step toward the ultimate elicitation of VRC01-class bnAbs that could protect people against HIV. This material relates to a paper that appeared in the March 25, 2016 issue of <i>Science</i>, published by AAAS. The paper, by J.G. Jardine at Scripps Research Institute in La Jolla, CA, and colleagues was titled, "HIV-1 broadly neutralizing antibody precursor B cells revealed by germline-targeting immunogen."

Credit

J.G. Jardine <i>et al</i>. / <i>Science</i> (2016)

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