Target-Cell Resistance Simulation (VIDEO)
Caption
The Princeton researchers simulated attacker cells (red) equipped with T6S surrounding target cells (blue). From left to right, the colonies that are the smallest at the outset of the attack cannot rejuvenate quickly enough to overcome the attack. For target cells with the largest initial populations, although cells on the outside of the group are killed, the interior cells can multiply fast enough to replenish their overall numbers and withstand the assault. Once there are enough sensitive cells, the rate of growth exceeds the rate of killing, which limits the utility of T6S as an offensive weapon.
Credit
Simulation by David Borenstein, Lewis-Sigler Institute for Integrative Genomics
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