Figure 1 Schematic of the Mechanism How Invading Bacteria Expand in Endothelial Cells (IMAGE)

The University of Osaka

Figure 1 Schematic of the Mechanism How Invading Bacteria Expand in Endothelial Cells

Caption

This is a schematic of the mechanism how invading bacteria expand in endothelial cells. Endothelial cells cannot efficiently recognize invading GAS because of lower endothelial activity to ubiquitinate bacteria, leading to less bacterial clearance by autophagy. Clearance of GAS artificially coated with ubuiquitin in endothelial cells suggests that endothelial cells retains basic machinery required to carry out the process. It indicates that autophagy in endothelial cells could be a prospective therapeutic target for bacterial infection in future.

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Osaka University

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