Figure 3 (IMAGE) Institute for Basic Science Caption Comparing the specificity of the SpCas9 variants with a DNA sequence that has a single mismatch between the guide RNA and the target sequence. evoCas9 and the original SpCas9 exhibit the highest and the lowest specificity, respectively. Credit IBS Usage Restrictions Please indicate the credit. License Licensed content Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.