Figure 2 (IMAGE)

Kanazawa University

Figure 2

Caption

The pathway whereby RB controls CCL2. Loss of RB increases fatty acid oxidation (FAO) by activating AMP-activated protein kinase (AMPK) leading to inactivation of Acetyl-CoA carboxylase (ACC) which suppresses FAO. This promotes mitochondrial superoxide production and JNK activation which enhances CCL2 expression.

Credit

Kanazawa University

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