New Salk Technology Adds Methyl Groups at Specific Positions on DNA, Allowing Targeted Correction of (IMAGE)

Salk Institute

New Salk Technology Adds Methyl Groups at Specific Positions on DNA, Allowing Targeted Correction of

Caption

This illustration represents editing of the epigenome by the new Salk technology. Top: open circles indicate aberrant methylation of the disease state. Bottom: Black circles indicate proper methylation induced by precise insertion of CpG-free DNA into a CpG island. The Salk team tested the technology in modeling colon cancer epimutations in human pluripotent cells, and to correct epigenetic defects in cells from a patient with Angelman syndrome (AS).

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Salk Institute

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