Simulation of Different Types of Treatment for Subjects with Alzheimer Disease (IMAGE)
Caption
Simulation of different types of treatment (inhibition of production by 80 percent maximally and activation of destruction of plaques to 600 percent) for subjects with Alzheimer disease according to 'cutting regime' (CR) and 'progressive regime' (PR). For PR, the maximal value of therapeutic intervention is the same as for the CR. Therapy simulations are compared with levels of normal values (light green area on a) and the model forecasted trajectory for normal subjects (dashed green line). Red arrows indicate the time at which the biomarker was no longer contained in the region of normal values. Two ages of therapy start were used for humans: 60 years (left) and 75 years (right). Black and cyan lines are overlapping on the right column panels, predicting absence of difference for two regimens of DT at this stage, the same for release inhibition (RI; orange and violet). . Ab, amyloid beta; BC, brain cell; BIF, brain interstitial fluid.
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