Thalamostriatal Dysfunction and Conflicted Action in Aging (VIDEO)

Cell Press

Caption

Behavioral adaptation is essential to survive in an ever-changing environment. Here, Bertran-Gonzalez and his team show a specific deficit in thalamostriatal circuits that prevents normally aged mice from integrating new with previous learning during the adaptation of action, resulting in conflicted goal-directed behavior.

Credit

Matamales and Skrbis <i>et al</i>./<i>Neuron</i> 2016

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