Reconstruction of Fruit Fly Nervous System with Nanometer Resolution (IMAGE)

Max Delbrück Center for Molecular Medicine in the Helmholtz Association

Reconstruction of Fruit Fly Nervous System with Nanometer Resolution

Caption

Two virtual right-angled cross-sections through the complete nervous system of a fruit fly larva. The combination of expansion microscopy, light sheet microscopy and data processing now makes it possible to reconstruct this complex organ optically with nanometer resolution. These data have the potential to track individual nerve cells without complex electron microscopy and thus significantly accelerate studies to investigate neuronal function. Each section highlighted in color is a large 3D image that has been automatically assembled like a mosaic into an overall image hundreds of gigabytes in size.

Credit

Janelia / MDC

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