Cell Division (IMAGE)

Universität Bayreuth

Cell Division

Caption

Left: In a healthy cell separase becomes active only after NEK2A has already been degraded - MCL1 and BCL-XL are not cleaved. Right: In cells with a defective spindle assembly checkpoint cell division is sped up. The enzymatic activities of NEK2A and separase timely overlap (purple area) - apoptosis is triggered.

Credit

Image: Olaf Stemmann.

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