Reconstructing Ancestral Proteins (IMAGE) University of Groningen Caption This illustration shows the phylogenetic tree of FMO enzymes. The ancestral enzymes proved to be stable enough to study and revealed how FMOs metabolize toxic substances. This made it possible to reconstruct the effect of disease-causing mutations in FMO genes, like the mutation causing fish odour syndrome. Credit Fraaije lab, University of Groningen Usage Restrictions With credit License Licensed content Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.