Schematic of the behavioral tasks (IMAGE) RIKEN Caption Behavioral sequencing task for self-paced learning and flexibility, showing opposite rewarded corners where the mouse has to go back and forth. In one task, the diagonally opposite rewarded corners are alternated sequentially with the other, upon achieving the successful visit-rate criterion at one diagonal. In the other task only one of the two previously rewarded corners is switched. When these two tasks were mixed together (serial reversal-learning), the Suv39h2-deficient mice had difficulty adapting to changes in rules. Credit RIKEN Usage Restrictions credit RIKEN License Licensed content Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.