Schematic representation of SARS-CoV-2 RNA genome showing alternative conformations (IMAGE)

University of Groningen

Schematic representation of SARS-CoV-2 RNA genome showing alternative conformations

Caption

The genes are indicated as arrows. The new analysis method developed by the group of Incarnato allowed determining which regions are dynamic, and as such able to switch between alternative mutually-exclusive conformations. These include two important viral regulatory regions (marked in purple). Hopefully, blocking the ability of these regions to interconvert between alternative structures will provide an effective therapeutic strategy to counteract the infection. The RNA is marked in different colours, to allow for easy comparison of the different structures.

Credit

D. Incarnato, University of Groningen

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