Three-Dimensional Cultures Reveal How Oxidative Stress Evolves in Breast Cancer (1 of 2) (IMAGE)

American Association for the Advancement of Science (AAAS)

Three-Dimensional Cultures Reveal How Oxidative Stress Evolves in Breast Cancer (1 of 2)

Caption

Fluorescence staining for NRF2 (magenta), p53 (green), and nuclei (blue) in normal breast ducts (encircled by extracellular matrix in white) and invading triple-negative breast cancer cells surrounding the ducts. This material relates to a paper that appeared in the Apr. 14, 2019, issue of Science Signaling, published by AAAS. The paper, by E.J. Pereira at University of Virginia in Charlottesville, VA; and colleagues was titled, "Sporadic activation of an oxidative stress-dependent NRF2-p53 signaling network in breast epithelial spheroids and premalignancies."

Credit

[Credit: Samples stained by E.J. Pereira and imaged by K.A. Janes]

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