An Alternative, More Stable Gene Drive (2 of 4) (IMAGE)

American Association for the Advancement of Science (AAAS)

An Alternative, More Stable Gene Drive (2 of 4)

Caption

Inheritance and spread of a gene drive construct, D, in a population of individuals with two copies of the wild-type gene, W. The gene drive construct induces a double-strand break at its own position on the homologous chromosome which is repaired either by homologous recombination, converting the individual to a DD homozygote, or by non-homologous end joining, producing a small mutation at the cut site which results in a drive-resistant allele. This material relates to a paper that appeared in the 05 April 2017, issue of Science Advances, published by AAAS. The paper, by C. Noble at Harvard University in Cambridge, Mass., and colleagues was titled, 'Evolutionary dynamics of CRISPR gene drives.'

Credit

Noble <i>et al.</i> <i>Sci. Adv</i>. 2017;3:e1601964

Usage Restrictions

Please cite the owner of the material when publishing. This material may be freely used by reporters as part of news coverage, with proper attribution. Non-reporters must contact <i>Science</i> for permission.

License

Licensed content

Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.