image: Inheritance and spread of a gene drive construct, D, in a population of individuals with two copies of the wild-type gene, W. The gene drive construct induces a double-strand break at its own position on the homologous chromosome which is repaired either by homologous recombination, converting the individual to a DD homozygote, or by non-homologous end joining, producing a small mutation at the cut site which results in a drive-resistant allele. This material relates to a paper that appeared in the 05 April 2017, issue of Science Advances, published by AAAS. The paper, by C. Noble at Harvard University in Cambridge, Mass., and colleagues was titled, 'Evolutionary dynamics of CRISPR gene drives.' view more
Credit: Noble <i>et al.</i> <i>Sci. Adv</i>. 2017;3:e1601964