Enlisting the Newly Discovered L-IST RNA in the Fight Against Type 2 Diabetes (IMAGE)

Tohoku University

Enlisting the Newly Discovered L-IST RNA in the Fight Against Type 2 Diabetes

Caption

A schematic of the discovery. Selenoprotein P (SeP), which is synthesized and secreted by the liver worsens diabetes when it is in excess. The novel gene "L-IST" binds to SeP mRNA and suppresses the synthesis of SeP protein. Additionally, epigallocatechin gallate, a major component of green tea and known to have a preventive effect on diabetes, increases L-IST and lowers SeP protein.

Credit

Y Mita et al.

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Credit: Y Mita et al.

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