Fragments of a Support Structure Drive Airway Abnormalities in Asthma (IMAGE)

American Association for the Advancement of Science (AAAS)

Fragments of a Support Structure Drive Airway Abnormalities in Asthma

Caption

Mice missing the gene for LTA4 showed heightened airway resistance and remodeling (top right) compared to controls. This effect was mitigated by neutralizing PGP with a compound named RTR (bottom right). This material relates to a paper that appeared in the Aug. 22, 2018, issue of Science Translational Medicine, published by AAAS. The paper, by D.F Patel at Imperial College London in London, UK; and colleagues was titled, "An extracellular matrix fragment drives epithelial remodeling and airway hyperresponsiveness."

Credit

D.F. Patel <i>et al., Science Translational Medicine</i> (2018)

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