Close-Up View of Three-Part Protein Interaction (IMAGE)

Howard Hughes Medical Institute

Close-Up View of Three-Part Protein Interaction

Caption

A close-up view of the three-component interaction between synaptotagmin (yellow), complexin (blue), and the SNARE complex (purple and red) in a brain cell. The curly helix of complexin nestles near a helix in a synaptotagmin protein, and is arranged so that twists of the helices align like the threads of a screw. These helices rest atop helices of the SNARE complex.

Credit

Zhou et al./ <i>Nature</i> 2017

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