Metastasis and Drug Resistance in Cancerous Cells (IMAGE)

Salk Institute

Metastasis and Drug Resistance in Cancerous Cells

Caption

A mammary gland organoid (a miniature version of the mammary gland grown in a dish) contains a fraction of cells that possess high levels of the gene Sox10 (blue). Sox10 corresponds to higher levels of stem-like plasticity, which gives these cells the ability to churn out many cell types as well as the power to migrate. In cancerous cells, these features lead to metastasis and drug resistance. Two types of proteins (cytokeratin-14, red, and cytokeratin-8, green) indicate distinct types of cells generated in this organoid from a single mammary cell expressing Sox10.

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Salk Institute

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