Cortical Grey Matter (IMAGE)

Society for Neuroscience

Cortical Grey Matter

Caption

This is a 3D reconstructed confocal image depicting cortical grey matter of a mouse after repetitive diffuse mild traumatic brain injury (rdTBI). We demonstrate a new subtype of atypical reactive astrocytes characterized by downregulation of homeostatic proteins: glutamate transporter 1 (blue) and S100β (green). Interestingly, atypical astrocytes do not undergo cell death after rdTBI, but rather have an enhanced expression of fluorescent protein tdTomato (red). In our model, mice develop spontaneous seizures and we link post-traumatic epileptogenesis with atypical astrocytes.

Credit

Oleksii Shandra

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