Figure 1 (IMAGE)

Centro Nacional de Investigaciones Cardiovasculares Carlos III (F.S.P.)

Figure 1

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Mice have a life expectancy a little over 2 years. Both mice in the image are 2 years old and have been reared under the same conditions. Nonetheless the mouse on the right has aged normally and shows evident signs of superior health compared with its partner: it has more abundant and more lustrous fur, is more robust, has more muscular mass, and is more active. The only genetic difference between the mice is that they have each inherited a different healthy mitochondrial DNA variant from their mothers. These distinct variants of healthy (non-pathogenic) mitochondrial DNA have substantially different effects on the quality of aging.

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