Intestinal Cells (IMAGE) Carnegie Institution for Science Caption The cellular structure of the intestine responds to specific nutrients in the diet. Here, a fruit fly gut is shown—each blue circle is the nucleus of an intestinal cell—which has doubled its normal number of hormone-producing cells (pink dots) following a diet high in cholesterol. The paper by Obniski, Sieber, and Spradling reports such changes in several tissues, shows they have long-lasting effects on metabolism and cancer susceptibility, and documents the likely underlying mechanism. Credit Carnegie’s Rebecca Obniski, Matthew Sieber, and Allan Spradling Usage Restrictions With credit License Licensed content Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.