Chromatin with and without ChromEM Dye (IMAGE)

Salk Institute

Chromatin with and without ChromEM Dye

Caption

Chromatin structure determines the function of the human genome. To visualize chromatin within intact cells, a method called ChromEM stains DNA and paints chromatin with a metal dust. The metal-coated chromatin is imaged by electron microscopy to generate a 3-D volume that reveals chromatin structure and organization. A single slice from the 3-D volume is shown here. Detailed chromatin structures are seen in a ChromEM stained cell (right panel, dark structures), but not in an unstained cell (left panel).

Credit

Salk Institute/Clodagh O'Shea/UCSD/Mark Ellisman

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