Weapon of the Immune System with a Built-In Safety Catch (IMAGE)

University of Bonn

Weapon of the Immune System with a Built-In Safety Catch

Caption

In a urinary tract infection, the migration of neutrophils (red cell) from the blood (red vessel, above) to the infection is only possible following a consultation between helper (yellow) and sentinel macrophages (green). Via the positive signal of the helper macrophages (thumbs up), the sentinel macrophage produces the protein CXCL2 (key) which allows the neutrophils to migrate through the basal membrane of the uroepithelium (chain with lock).

Credit

Graphic: P. Schreiner and M. Gerhards/UKB

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