Inhibitor binding to the signal proteins FAK and PYK2 (with text) (IMAGE)

Goethe University Frankfurt

Inhibitor binding to the signal proteins FAK and PYK2 (with text)

Caption

Upper part: Long residence time. An inhibitor (left: stick model) binds to the signal molecule FAK (right: part oft the FAK protein depicted as calotte model with spheres). The structural change of FAK causes hydrophobic contacts (yellow, so-called DFG motif) and a long-lasting engagement. Lower part: Short residence time. PYK2 signal protein does not change its structure upon inhibitor binding, thus resulting in a fast inhibitor dissociation. Graphics: Knapp Laboratory, Goethe University Frankfurt

Credit

Knapp Laboratory, Goethe University Frankfurt

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