Approved Cancer Immunotherapy Drug Blocks Opioid Pain Relief in Animals (2 of 2) (IMAGE)

American Association for the Advancement of Science (AAAS)

Approved Cancer Immunotherapy Drug Blocks Opioid Pain Relief in Animals (2 of 2)

Caption

Mu opioid receptor and PD-1 are co-expressed in pain-sensing sensory neurons. Morphine antinociception is diminished in mice or nonhuman primates by immunotherapy targeting PD-1, whereas PD-L1 enhances morphine antinociception in mice. This material relates to a paper that appeared in the Feb. 19, 2020, issue of Science Translational Medicine, published by AAAS. The paper, by Z. Wang at Duke University Medical Center in Durham, NC; and colleagues was titled, "Anti-PD-1 treatment impairs opioid antinociception in rodents and nonhuman primates."

Credit

[Credit: Drs. Zilong Wang and Changyu Jiang]

Usage Restrictions

Please cite the owner of the material when publishing. This material may be freely used by reporters as part of news coverage, with proper attribution. Non-reporters must contact <i>Science</i> for permission.

License

Licensed content

Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.