Figure 1. Design Strategy of Frankenbodies (IMAGE)

_Tokyo Institute of Technology

Figure 1. Design Strategy of Frankenbodies

Caption

A diverse set of scFv scaffolds proven to fold and function in living cells. Onto these scaffolds, we loop graft all complementarity determining regions (CDRs, or loops) from an epitope-specific antibody. Depending on the compatibility of the scaffold and CDRs, this produces a hybrid scFv that retains the stability of the scaffold, while acquiring the specificity of the grafted CDRs.

Credit

Hiroshi Kimura, Timothy J. Stasevich

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