Figure 2 (IMAGE) SingHealth Caption Figure 2. Scientific model illustrating the different use of fatty acid in specific cancer cell states. In the more aggressive mesenchymal cell state, beta-oxidation is activated to burn fatty acid; this generates acetyl-CoA – a bioactive metabolite – for the epigenetic control of genes responsible for the epithelial-mesenchymal transition and cancer metastasis. Upon the mesenchymal-to-epithelial transition, which is induced by retinoid treatment, fatty acid is stored as lipids instead. By preventing the ability of cancer cells to oxidise fatty acid, the less aggressive epithelial cancer cells are unable to acquire aggressive behaviour and less likely to metastasise. Credit Credit to National Cancer Centre Singapore Usage Restrictions nil License Original content Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.