Stripping (2 of 2) (IMAGE)

Rice University

Stripping (2 of 2)

Caption

Rice University researchers detailed the molecular stripping mechanism responsible for "broadcasting" genetic transcription instructions through a genetic switch known as NFkB-DNA-IkB. When triggered, the IkB inhibitor (blue) tells NFkB proteins (green) to release from DNA binding sites (red) to stop transcription of multiple genes at once. The IkB protein binds to NFkB and forces a physical twist in the protein that releases its grip on DNA.

Credit

Wolynes Lab/Rice University

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