The Protein Complex that Begins DNA Replication (IMAGE)

Cold Spring Harbor Laboratory

The Protein Complex that Begins DNA Replication

Caption

The human ORC complex when fully assembled is ring-shaped, as shown in these images at atomic resolution, secured via x-ray crystallography and cryo-electron microscopy. Bottom image: DNA (grey) fits through the 'ring' as a bolt fits snugly through the center of a nut.

Credit

Courtesy, Joshua-Tor Lab, CSHL

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