Greg Wang, Ph.D., UNC Lineberger Comprehensive Cancer Center (IMAGE)

UNC Lineberger Comprehensive Cancer Center

Greg Wang, Ph.D., UNC Lineberger Comprehensive Cancer Center

Caption

UNC Lineberger's Greg Wang, Ph.D., and colleagues have identified an evolutionarily conserved pathway to be responsible for "closing down" gene activity in the mammalian cell. The finding is closely related to the Polycomb pathway defined decades ago by a set of classic genetic experiments carried out in fruit flies. They report the BAHCC1 protein is critically involved in silencing genes and acts as an integral component of the Polycomb gene-repressive pathway in mammalian cells.

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UNC Lineberger Comprehensive Cancer Center

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