The cell senescence suppression mechanism of Vitamin B2 (IMAGE)
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Cells under stress produce SLC52A1 and increase their absorption of Vitamin B2 from outside the cell. Once inside the cell, the Vitamin B2 is converted into FAD and increases mitochondrial energy production by becoming a coenzyme of mitochondrial respiratory chain complex II. As a result of this, AMPK and p53 (which induce cellular senescence) are inactive, therefore stress-mediated cellular senescence is suppressed.
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Taiki Nagano
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