Thick Skin and Thin Skin (IMAGE) DOE/Lawrence Berkeley National Laboratory Caption At top, the epidermis of a wild-type mouse is thick, and its granular layer is prominent. At bottom, the epidermis of a Satb1 knockout mouse is significantly thinner, and its granular layer is diminished. Satb1 controls the expression of many genes responsible for epidermal architecture. Credit University of Bradford, Lawrence Berkeley National Laboratory Usage Restrictions None License Licensed content Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.