Figure 2. Mutant AIOLOS interfere with IKAROS via heterodimers --Heteromeric interference. (IMAGE)

_Tokyo Medical and Dental University

Figure 2. Mutant AIOLOS interfere with IKAROS via heterodimers --Heteromeric interference.

Caption

AIOLOS forms heterodimer with its partner IKAROS. They comprise transcription factor complex which regulates genes involved in lymphocyte development. In the patients and the patient-mimic mouse model, mutant AIOLOS forms heterodimer with IKAROS and interferes with its function by blocking AIOLOS-IKAROS bindings to their physiological binding sites and sequestrating IKAROS to non-physiological binding regions in the form of heterodimers.

Credit

Department of Pediatrics and Developmental Biology,TMDU

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