Neighboring Neruons Don't Necessarily Project to Same Destinations (IMAGE)

Cold Spring Harbor Laboratory

Neighboring Neruons Don't Necessarily Project to Same Destinations

Caption

'Bulk' labeling methods now widely in use to map brain connections are able to determine that neurons in the 'source' region (left side) project to three green-shaded regions (right side), but are not able to distinguish the specific destinations of individual neurons in the source region. MAPseq enables such distinction -- in this example, showing that neurons bearing specific 'barcodes' (vastly reduced in complexity here for demonstration purposes) carry those barcodes to some of the 3 'destinations' but not necessarily all of them, or the same ones as other neurons in the source region.

Credit

Zador Lab, CSHL

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