Regulatory gene circuit of the master transcription factors for EC differentiation (IMAGE)

Kumamoto University

Regulatory gene circuit of the master transcription factors for EC differentiation

Caption

Schematic representation of the genetic regulatory network linking four transcription factors and EC differentiation. TFs: transcription factors, SMC: smooth muscle cells, HPC: hematopoietic stem cells, Epi: epithelial cells, CM: cardiomyocytes. Representative activated (red) or repressed (blue) genes by each transcription factor are shown in the box. Adapted from: Y. Kanki, R. Nakaki, T. Shimamura, T. Matsunaga, K. Yamamizu, S. Katayama, J. Suehiro, T. Osawa, H. Aburatani, T. Kodama, et al., "Dynamically and epigenetically coordinated gata/ets/sox transcription factor expression is indispensable for endothelial cell differentiation.," Nucleic acids research, Mar. 2017. DOI: 10.1093/nar/gkx159

Credit

Professor Takashi Minami

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