Biological Connections Between Genes Associated with Height (IMAGE)

Boston Children's Hospital

Biological Connections Between Genes Associated with Height

Caption

Using computational methods, the investigators identified sets of genes that are predicted to share biological functions with each other and that strongly overlap with the list of height-associated genes. The redder squares indicate stronger connections between the corresponding gene (listed along the bottom) and the predicted biological function (listed along the right). The magnified portion of the figure depicts a cluster of 15 genes that are all strongly connected to the same growth-related gene sets. This cluster includes 7 genes known to cause skeletal growth disorders and 8 closely related genes that are now newly implicated as being important for skeletal growth.

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Image courtesy GIANT Consortium investigators

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