HSPB8 Protein (IMAGE)

Arizona State University

HSPB8 Protein

Caption

A protein called HSPB8 was identified in the screen. HSPB8 appears to confer resistance by the surprising mechanism of blocking autophagy, a process where cells escape death by consuming proteins inside the cell. Immunofluorescence images show that after silencing HSPB8 in all drug resistant subclones, the characteristic redistribution of anti-MAP LC3 into punctuate green structures appear, indicating active autophagy.

Credit

Laura Gonzalez, Biodesign Institute at Arizona State University

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