Discriminator Element (1 of 2) (IMAGE)

Rutgers University

Discriminator Element (1 of 2)

Caption

A crystal structure of a bacterial transcription initiation complex reveals that the initiation factor recognizes the promoter -10 element and promoter discriminator element through interactions that include the unstacking of DNA bases and their insertion into pockets formed by residues of [Interactions of σ (yellow) with the -10 element (blue) and discriminator element (light blue) are illustrated. DNA bases that are unstacked and inserted into pockets are indicated with cyan boxes. An amino acid of σ that can be crosslinked to discriminator position -5 is indicated in green.]

Credit

Yu Zhang and Richard H. Ebright, Rutgers University

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