PMO Penetrates Infiltrating Inflammatory Cells Targeting Regions of Active Muscle Regeneration (IMAGE)

Children's National Hospital

PMO Penetrates Infiltrating Inflammatory Cells Targeting Regions of Active Muscle Regeneration

Caption

PMO penetrates infiltrating inflammatory cells targeting regions of active muscle regeneration. a. PMO uptake within infiltrating macrophages targeting areas of regeneration after systemic F-PMO delivery in the experimental model. PMO delivery to muscle fibers is marked by arrow, while PMO-loaded inflammatory cells (macrophages, Mφ) are marked by arrowhead. b. Widespread PMO accumulation within a large population of infiltrating macrophages and other inflammatory cells targeting degenerating muscle fibers.

Credit

J.S. Novak, et al., Nature Communications

Usage Restrictions

With credit

License

Licensed content

Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.