Proposed immunological mechanisms of severe COVID-19 (IMAGE)

Kumamoto University

Proposed immunological mechanisms of severe COVID-19

Caption

A major difference between mild and severe cases of COVID-19 may be the extreme activation of T cells as they react to the virus. In mild cases, T cell activation is slowed by the introduction of Foxp3 transcription factor. In severe cases, on the other hand, Foxp3 is not induced which causes a run-away effect on T cell activation resulting in severe immune response.

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Associate Professor Masahiro Ono

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<p>Adapted from Fig. 5 of <a href="https://www.frontiersin.org/articles/10.3389/fimmu.2020.589380/full">Kalfaoglu, B. et al., Frontiers in Immunology, 2020</a>. </p> <p>This image is made available under the terms of <a href="https://creativecommons.org/licenses/by/4.0/">CC by 4.0</a>. Any further distribution of this work must follow the terms of this license. </p>

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