CHAMP: Chip Hybridized Affinity Mapping Platform (IMAGE) University of Texas at Austin Caption A stitched image of fluorescently-labeled DNAs on the surface of a Next-Generation Sequencing flowcell. Images were collected on a prism-TIRF microscope and used in the Chip Hybridized Affinity Mapping Platform (CHAMP), a newly described framework for high-throughput, quantitative analysis of protein-DNA interactions on synthetic and genomic DNA. With CHAMP, Jung et al. revealed the highly-specific sequence dependence for target binding and nuclease recruitment by Cascade, a Type 1 CRISPR-Cas system. Credit Stephen Jones Jr./Univ. of Texas at Austin Usage Restrictions None License Licensed content Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.